Homocysteine lowering interventions for preventing cardiovascular events.
This article has been cited by other articles in PMC. Abstract In this study, we investigated the hepatoprotective effects of aged black garlic ABG in rodent models of liver injury.
D-galactosamineinduced hepatocellular damage was also suppressed by ABG treatment. However, ABG does not affect the elevation of alkaline phosphatase ALPa marker of hepatobilliary damage, in rats treated with carbon tetrachloride or D-galactosamine.
These results demonstrate that ABG has hepatoprotective effects and suggest that ABG supplementation might The effect of alcohol to abg a good adjuvant therapy for the management of liver injury. Aged black garlic, Liver injury, Carbon tetrachloride, D-galactosamine, Non-alcoholic fatty liver disease INTRODUCTION Garlic has long been used as a medicinal food and recent studies have validated a variety of its biological activities, including cancer prevention, anti-thrombosis and cardioprotection 1 - 3.
In spite of these beneficial effects, consumption of raw garlic is not prevalent in many areas because of its unpleasant odor and adverse effects, such as gastrointestinal disorder and hemolytic anemia 45.
Allicin and lipidsoluble sulfur compounds derived from allicin have been known to be involved in these adverse effects 46. Aged garlic extract AGE, Kyolic is a preparation produced by long-term extraction of fresh garlic in aqueous ethanol at room temperature 7. AGE has been known to contain water-soluble allyl amino acid derivatives, stable lipid-soluble allyl sulfides, flavonoids and saponins, but not allicin anymore 8.
AGE has also been shown to exert various biological activities, including anti-cancer, antioxidant and immune-potentiating effects without already known adverse effects of raw garlic 7 - Recently, another garlic preparation, called aged black garlic ABGwas marketed 11 ABG is produced by ageing whole garlic at high temperature and high humidity 13 It has been reported that unstable compounds of raw garlic are converted into stable compounds, such as Sallylcysteine SACafter this processing.
ABG was shown to have stronger antioxidant activity than raw garlic both in vitro and in vivo 11 It was also reported that ABG is beneficial for prevention of cancer and diabetes 1116 Moreover, ABG was reported to have a protective effect against chronic alcohol-induced liver injury in rats Based on these reports, we hypothesized that ABG might also have protective effects against liver injuries induced by various insults.
In the present study, we examined the effects of ABG on carbon tetrachloride CCl4 - or D-galactosamine-induced liver damage. We also investigated the protective effect of ABG on high-fat diet HFD -induced hepatic steatosis and subsequent liver injury. All reagents were purchased from Sigma-Aldrich St.
Animals were allowed to acclimate to the local environment for at least 1 week before use. The raw material of garlic was cultivated in Namhae, Gyeongnam, Republic of Korea.
The residue was homogenized and sterilized to yield ABG used in this study. CCl4- or D-galactosamine-induced liver injury model. Liver was also removed, weighed and fixed in formalin and liquid nitrogen for histopathology. High-fat diet-induced liver steatosis and injury model.
The body weight was recorded once a week. At the end of experiment, blood was collected from the posterior vena cava and plasma was prepared for biochemical analysis.
Liver, subcutaneous fat, epididymal fat and mesenteric fat were removed surgically, weighed and stored in formalin and liquid nitrogen for further analysis. Fixed livers were embedded in paraffin and thin sections were made.
The sections were stained with hematoxylin and eosin and the slides were photographed. For detection of lipid deposition, liver sections were prepared from frozen liver and stained with Oil Red O as described previously As shown in Table 1liver weight was increased significantly by CCl4 administration, which is in consistent with previous reports 20 However, treatment of rats with ABG inhibited CCl4-induced increase in liver weight in a concentration-dependent manner, although the effect was not statistically significant Table 1.A blood gas test measures the amount of oxygen and carbon dioxide in the blood.
It may also be used to determine the pH of the blood, or how acidic it is. The test is commonly known as a blood gas. The Effect of Alcohol to Abg.
Topics: Carbon dioxide, One physical effect of alcoholism is causing cancer in the liver, kidney and stomach. Alcohol abuse is . Hepatoprotective effect of ABG on D-galactosamineinduced hepatic injury.
To further investigate the protective effect of ABG against hepatotoxicant-induced liver damage, we examined the effect of ABG on D-galactosamineinduced liver damage in SD rats.
An arterial blood gas (ABG) Before the arterial blood gas test, your doctor or another health care worker may apply pressure to the arteries in your wrist for several seconds.
Do not use alcohol or medications that contain alcohol while you are receiving treatment with morphine. This may increase nervous system side effects such as drowsiness, dizziness, lightheadedness, difficulty concentrating, and impairment in thinking and judgment.
Long-term effects of alcohol consumption. Jump to navigation Jump to search. Long-term effects of alcohol; Most significant of the possible long-term effects of ethanol.
There is a protective effect of alcohol consumption against active infection with H. pylori In contrast, alcohol intake.